The protests over the police shooting of Breonna Taylor have been going on in the city park for weeks.
The LMPD noted in the statement that Jefferson Square Park would remain closed for several hours.
On 13 March, Taylor, 26, was shot dead by police in her home as officers entered to execute a search warrant targeting her former boyfriend.
The death of Taylor, George Floyd in Minneapolis, and other African Americans served as a catalyst for protests against police brutality throughout the United States as well as the world.
One killed in shooting at Breonna Taylor protest in Jefferson Square Park in Louisville, Kentucky. Police have cleared the area to investigate.
One person has died, and another one was injured in a shooting during protests in the US city of Louisville, the city’s Police Department (LMPD) said in a statement.
“Just about 9 p.m. [01:00 GMT Sunday], there were reports of shots fired in Jefferson Square Park. Calls then came in that Sheriff’s Department personnel were in the park performing life-saving measures on a male who eventually died at the scene. A short time later, we got a report of another shooting victim at the Hall of Justice. That person was taken to University Hospital with non-life threatening injuries,” the statement, posted on Facebook, read.